Indiana Evans had an interest in performing since the age of five, when she would perform for family and friends. At the age of seven, Indiana's parents enrolled her into dance lessons, which started with ballet and then evolved to jazz and tap.
Before working on Home and Away, Indiana Evans started high school at Newtown High School of the Performing Arts, but left after two weeks to focus on her acting career. She then took up a correspondence course until she turned.
In 2003, Evans had a guest role as Milly Roberts in an episode of All Saints. She then landed the principal role in an American campaign for Kool Aid. She also appeared in the Australian comedy sketch show Comedy Inc. The same year, she also had the role of Abby Oakley on the television series, Snobs.
In 2004, as her part in Snobs ended, Evans was asked to audition for the role of Matilda Hunter in the series Home and Away and won the part. During her time at Home and Away, she appeared occasionally as a guest on Girl TV, a daily TV magazine show. In 2005, she was nominated for a Logie Award for "Most Popular New Female Talent" for playing the role of Matilda.
On 20 April 2008, it was incorrectly reported that Evans was denied a contract renewal from the producers of Home and Away by Australian newspaper The Daily Telegraph. In the 3 May edition of magazine TV Week, Evans stated to journalist Carolyn Stewart that the producers offered her a contract extension, however she "was ready to move on", and that the incorrect report was "surprising". She made her last appearance on the soap in July 2008.
Evans guest starred as China Williams in the Australian drama show The Strip in 2008. She also appeared in two short films, Burden and At the Tattooist.
In 2009, Evans appeared as Kylie Watson in the television film A Model Daughter: The Killing of Caroline Byrne. She then appeared in the role of Isabella 'Bella' Hartley for the third series of children's show H2O: Just Add Water, taking the place of departing actress Claire Holt. In addition to her role, she also sang the theme song for the show, "No Ordinary Girl", as well as various other songs during the course of the series.
Evans starred in the feature film Arctic Blast, released in 2010, playing the character Naomi Tate.
In 2011, Evans played Tatum Novak in the Australian legal drama Crownies on ABC-1.
In February 2012, it was announced that Evans had been signed to play the female lead television re-make of the 1980 film, The Blue Lagoon.